Platelet-rich Plasma for Managing Pain and Inflammation in Osteoarthritis
Includes easy to comprehend diagrams.
Osteoarthritis (OA) is a common disease involving joint damage, an inadequate healing response and progressive deterioration of the joint architecture. Autologous blood-derived products, such as platelet-rich plasma (PRP), are key sources of molecules involved in tissue repair and regeneration. PRP contains hundreds of different molecules; cells within the joint add to this milieu by secreting additional biologically active molecules in response to PRP. The net results of PRP therapy are varied and can include angiogenesis, the production of local conditions that favour anabolism in the articular cartilage, or the recruitment of repair cells.
Read more in Platelet-rich Plasma for Managing Pain.pdf
Meeting current musculoskeletal health demand through deeper insights into tissue homeostasis and regeneration
The complexity of failed healing may be challenged with interventions that target multiple mechanisms, such as cell therapies and platelet-rich plasma (PRP) therapies. These treatments are distinct from those delivering the classic drug that triggers a single target. PRP, an autologous plasma fraction of peripheral blood, is the simplest regenerative medicine intervention that has rapidly extended to multiple medical fields, mainly because of its ease of use and biosafety. The concept is that PRP induced healing by providing a molecular milieu for regeneration. In this context, PRP aims to reactivate failed healing mechanisms, likely providing signalling factors that help to resume inflammation and angiogenesis.
Read more in Meeting Current Musculoskeletal Health Demands.pdf
Platelet-rich plasma in the conservative treatment of painful tendinopathy: a systematic review and meta-analysis of controlled studies
Painful tendon conditions are frequent in orthopaedics and sports medicine, and challenging to treat. Alternatively, the capacity for tissue repair can be reduced or impaired because of intrinsic factors such as advanced age, or genetic predisposition. Also, the capability for tissue repair may be weakened and tendon turnover disrupted due to pathological biochemical changes associated with metabolic diseases such as diabetes mellitus, hypercholesterolemia or gouty arthritis among others. Research findings on the use of PRP injections in tendinopathy show that they can increase cell number, stimulate precursor cell differentiation and collagen fiber density, and restore tissue architecture.
Read more in PRP Tendinopathy Metaanalysis.pdf